What is the treatment of hemophilia

To diagnose a bleeding disorder and whether it may be inherited or acquired, your doctor may order one or more of the following tests.

  • A complete blood count (CBC) to measure many different parts of your blood, such as the number of blood cells and platelets. If the number of platelets is too low, you may have a platelet disorder instead of a clotting factor disorder.
  • A partial thromboplastin time (PTT) test, also called an activated PTT (aPTT), to measure how long it takes blood to clot. It can help determine whether certain clotting factors are involved.
  • A prothrombin time (PT) test is another test to measure how long it takes blood to clot. It measures clotting factors that the PTT test does not.
  • A mixing test to help determine whether the bleeding disorder is caused by antibodies blocking the function of clotting factors, such as with autoimmune disorders or acquired hemophilia.
  • Von Willebrand factor (vWF) tests to measure the amount of von Willebrand factor, whether the factors are working correctly, or which type of VWD you have.
  • Clotting factor tests, also called factor assays or a coagulation panel, to determine whether certain clotting factors are missing or show up at lower levels than normal, which can indicate the type and severity of the bleeding disorder. For example, if you have very low levels of clotting factor VIII, you may have hemophilia A.
  • A Bethesda test to look for antibodies to factor VIII or IX
  • Factor XIII antigen and activity assays to look for factor XIII deficiency
  • Genetic testing to determine if particular genes may be causing the bleeding disorder. Your doctor may refer you or your child to a specialist in genetic testing.

For some bleeding disorders, such as hemophilia, the clotting factor test can tell you how severe the disorder is. Below are possible results from testing for hemophilia A:

  • Severe hemophilia A: <1% of factor VIII detected
  • Moderate hemophilia A: 1% to 5% of normal factor VIII levels
  • Mild hemophilia A: 6% to 30% of normal factor VIII levels

For hemophilia A, the amount of factor VIII is measured and compared to normal amounts. If you have mild hemophilia, you would have 30% or less of the factor VIII levels that a person without a bleeding disorder would have. If you have moderate hemophilia, you would have less than 6% of normal factor VIII levels. If you have severe hemophilia, there would be no detectable levels of factor VIII.